Sub-Center for Biology of CERN published a series of protocol books, including “Survey, Observation and Analysis of Terrestrial Biocommunities”, “Protocols for Standard Biological Observation and Measurement in Terrestrial Ecosystems”, “Quality Assurance and Quality Control of Data for Long-term Biological Observation in Terrestrial Ecosystems’’. These publications explicitly described the variables, methods, protocols, data quality control measures, data report and assessment process, quality management system of biotic observation in CERN. They play a central role in ensuring biological observation and data management in all CERN stations with unified protocols.